Pensedyl Effects part-02
P armacology:- phenothiazine derivative P romethiazine, a phenothiazine derivative is structurally different from the neuroleptic phenothiazines with similar but different effects. Another notable use of promthazine is as a local anesthetic by blockade of sodium channels. Chemistry:- promethiazine hydrochloride Solid promethiazine hydrochloride is a white to faint yellow, odorless, crystalline power. Its hydrochloride salt is freely soluble in water and somewhat soluble in Alcohol. Chemical and Pharma Co-kinetic Data:- Formula :- C17H20N2S Molar Mass :- 284.42 g/mol Bio availability :- 88% absorbed but after 1st pass metabolism reduced to 25% absolute bio ava...